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Organic Food Grade Immature Sweet Oranges Extract Diosmin Powder CAS 520-27-4

Organic Food Grade Immature Sweet Oranges Extract Diosmin Powder CAS 520-27-4

  • Organic Food Grade Immature Sweet Oranges Extract Diosmin Powder CAS 520-27-4
  • Organic Food Grade Immature Sweet Oranges Extract Diosmin Powder CAS 520-27-4
  • Organic Food Grade Immature Sweet Oranges Extract Diosmin Powder CAS 520-27-4
  • Organic Food Grade Immature Sweet Oranges Extract Diosmin Powder CAS 520-27-4
Organic Food Grade Immature Sweet Oranges Extract Diosmin Powder CAS 520-27-4
Product Details:
Place of Origin: SiChuan,China
Brand Name: YHF
Certification: ISO/HACCP/KOSHER/GMPs/FDA
Model Number: 520-27-4
Payment & Shipping Terms:
Minimum Order Quantity: Minimum standard package, for the detail, please refer to "regular package"
Price: Negotiate
Packaging Details: 25kg/drum
Delivery Time: 30 work days after receiving firm order.
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Detailed Product Description
Product Name: Diosmin Type: Herbal Extract
CAS: 520-27-4 Specification: EP10.0
Appearance: Light Yellow Hygroscopic Powder Application: Dietary Supplement, Health Food
Test Method: HPLC/UV Brand Name: YHF
High Light:

Immature Sweet Oranges Extract Diosmin Powder

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Organic Food Grade Diosmin Powder

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Diosmin Powder CAS 520-27-4

Organic Food Grade Immature Sweet Oranges Extract Diosmin Powder CAS 520-27-4
 
Detailed Product Description:
 
Organic Food Grade Immature Sweet Oranges Extract Diosmin Powder CAS 520-27-4 0
Diosmin is manufactured from citrus fruit peels as a phlebotonic non-prescription dietary supplement used to aid treatment of hemorrhoids or chronic venous diseases, mainly of the legs.Diomin was first isolated from the Scrophularia nodosa in 1925 and was first used as a therapeutic drug in 1962.
 

Product nameDiosmin
CAS NO.520-27-4
Raw materialHesperidine
FormulaC28H32O15
MOL WT609
Test methodHPLC
Place of originSiChuan,China(Mainland)
StorageDry place

 

Specification:

 

DETERMINATIONSSPECIFICATIONS
AppearanceGrayish-yellow or light yellow hygroscopic powder.
SolubilityPractically insoluble in water, soluble in dimethyl sulphoxide, practically insoluble in ethanol(96 per cent). It dissolves in dilute solutions of alkali hydroxides.

Identification
(2.2.24 & 2.2.29Ph Eur.1611)

A. Infrared absorption spectrophotometry
Camparison:diosmin CRS

 B. The principal peak in the chromatogram obtained with the test solution is similar in retention time and size to the principal peak in the chromatogram obtained with reference solution (a)
Iodine(2.2.36&2.5.10Ph Eur.1611)≤0.1%

Related substances
(HPLC)
(2.2.29Ph Eur.1611)

Impurity A (Acetoisovanillone) ≤0.5%
Impurity B (Hesperidin) ≤ 4.0%
Impurity C ( Isorhoifolin) ≤3.0%
Impurity D (6-Iododiosmin) ≤0.6%
Impurity E (Linarin) ≤3.0%
Impurity F (Diosmetin) ≤2.0%
Any unspecified impurity ≤0.4%
Total of impurities ≤8.5%

Heavy metals
(2.4.8 Method C Ph Eur.1611)

≤20ppm
Hg (AAS)≤0.10ppm
Water (2.5.12Ph Eur.1611)≤6.0%
Sulphated ash (2.4.14Ph Eur.1611)≤0.2%

Assay on anhydrous basis
(2.2.29Ph Eur.1611)

90.0%~102.0% (on anhydrous basis)
Pyridine (2.4.24Ph Eur.1611)≤200ppm

Particle size
(by laser granulometry)

80%<2 micron

Microbiological test
(CP2010)

Total bacteria count :≤1000cfu/g
Moulds and yeasts :≤100cfu/g
Salmonella: Negative
E.Coli :Negative

 
Remarks: In a word, we can produce as per the client`s specific rquirements like particle size,color,solubility, signal heavy metal under Eu rules No629/2008, the other contaminants under EC1881/2006 and residual solvent under directive EC32/2009.
 

Product Function:

 
1.Diosmin prolongs the vasoconstrictor effect of norepinephrine on the vein wall, increasing venous tone, and therefore reducing venous capacitance, distensibility, and stasis.
2.Diosmin increases the venous return and reduces venous hyperpressure present in patients suffering from CVI.
3.Diosmin improves lymphatic drainage by increasing the frequency and intensity of lymphatic contractions, and by increasing the total number of functional lymphatic capillaries.
4.Diosmin with hesperidine decreases the diameter of lymphatic capillaries and the intralymphatic pressure.
5.At the microcirculation level, diosmin reduces capillary hyperpermeability and increases capillary resistance by protecting the microcirculation from damaging processes.
6.Diosmin reduces the expression of endothelial adhesion molecules,and inhibits the adhesion, migration, and activation of leukocytes at the capillary level.Diosmin leads to a reduction in the release of inflammatory mediators, principally oxygen free radicals and prostaglandins.
 

Application :

 

1. Diosmin is used to treat chronic venous insufficiency, hemorrhoids, joint edema, venous ulcer of lower extremity, premenstrual syndrome, microangiopathy in diabetic patients and upper extremity lymphedema secondary to traditional lung cancer treatment.

2. clinical application of compound preparation of diozin and hesperidin.

 
Company Profile:
 
Sichuan YuanHongFu Technology co., Limited(YHF) is specialized in herbs` harvesting, the development & manufacturing of botanical extracts and their derivatives, is dedicated to the extraction & purification & innovations of Natural Citrus and Sophorae Japonica L, as well as the structural modification of these natural ingredients(Derivatives) that service the pharmaceutical, nutraceutical, cosmetic and flovor industrial.

 
Our Advantage:
 
1. The factory have passed the ISO9001, Kosher, HALAL,FDA,Organic and Chinese Health Food GMP;
2. We inspect the manufacture process strictly and the quality can be controlled
3. We supply high quality products, reasonable price, prompt delivery
4. Our best quality extract with natural and pure. No additives, organically grown;
 
We all employee adhering to the business philosophy of "quality first, forging ahead", we have established long-term and stable cooperative relationships with many enterprises in domestic and overseas markets. With superior products and consummate services, all of our staff members sincerely welcome friends to visit us for negotiation and cooperation to create a better tomorrow.
 
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Contact Details
Sichuan Yuanhongfu Technology Co., Limited

Contact Person: Sophie

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